Fig. 1

Schematic chromosome patterns and ChIP-Chip results. a Horizontal bars represent the individual chromosomes of the parental strain 3153A, its aneuploid derivative Sor125(55), and the reference strain SC5314, as indicated. Chromosomes are designated from 1 to 7 and R, on the left, as their sizes decrease from top to bottom. For the chromosome sizes, see [8]. ChR refers to the chromosome containing a cluster of tandemly repeated rDNA units. Homologous chromosomes are indicated with “a” and “b.” [Adopted from 8]. b Graphic presentation of ChIP-Chip results showing acetylation of histone H4 and histone H3, as indicated, on the chromosomes of the mutant Sor125(55), compared to the parental strain 3153A. Each chromosome is presented with a single graph. The X-axis indicates the position of the probes on each chromosome in the reference strain SC5314, as annotated in genomic assambly 21 in CGD. The Y-axis shows the averaged log2 ratio Sor125(55) minus log2 ratio 3153A (see “Methods”). The horizontal red arrows on Ch 4 and Ch7 indicate the trisomic regions due to duplication of Ch4/7b (see Fig. 1a). The numbers on the right indicate the density of positive (top) and negative (bottom) peaks of acetylation on each chromosome, while the second values on the right for Ch4 and Ch7 indicate the density of positive and negative peaks within the trisomic regions. Asterisks indicate large negative peaks denoting apparent loss of H4 acetylation in Sor125(55)