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Fig. 4 | Epigenetics & Chromatin

Fig. 4

From: Histone isoform H2A1H promotes attainment of distinct physiological states by altering chromatin dynamics

Fig. 4

H2A1H-H2B dimer is less stable than the H2A2A3-H2B dimer. a, b Apparent fraction unfolded (Fapp) obtained from the analysis of the CD spectra of H2A1H-H2B and H2A2A3-H2B monitored during thermal and urea denaturation. c Fapp obtained from the analysis of the fluorescence spectra of H2A1H-H2B and H2A2A3-H2B monitored during urea denaturation. Error bar represents SEM of six independent experiments. d Comparative determination of the various parameters obtained by the CD and fluorescence spectra of H2A1H-H2B and H2A2A3-H2B. e Comparison of temperature of melting (Tm) of various H2A1H single, double mutants and H2A2A3 with H2A1H. f, g Ligplots depicting the interaction of the 51st residue of both H2A1H and H2A2A3 in the H2A–H2B dimer interface

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Epigenetics & Chromatin

ISSN: 1756-8935