Fig. 2

Genome-wide demethylation and de novo DNA methylation processes in the mammalian germline and in preimplantation embryos. The levels of global DNA methylation are indicated on the y-axis and are shown by a blue line for the paternal genome and a pink line for the maternal genome. The top bar schematically presents waves of demethylation followed by de novo methylation in F0–F3 generations