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Fig. 7 | Epigenetics & Chromatin

Fig. 7

From: Genome-wide search for Zelda-like chromatin signatures identifies GAF as a pioneer factor in early fly development

Fig. 7

DNA accessibility in WT and zld mutants. a Shown is the average FAIRE signal (DNA accessibility) in WT embryos for 2500 enhancer-like loci that are binned based on their ZLD (Y-axis) and GAF (X-axis) ChIP binding. b Same as A, using FAIRE data from maternal zld mutants [20]. Comparison of the two matrices shows that genomic regions with no GAF binding (in WT) are mostly affected by deletion of zld (left hand side of both matrices), while regions bound by GAF (right hand side) still show high DNA accessibility, suggesting that GAF could ac as a pioneer factor in early fly development, together or independently of Zelda

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