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Table 4 Summary of differentially methylated (FDR cutoff: 0.05) genes in hatchlings that are putatively involved in reptilian gonadogenesis

From: MeDIP-seq and nCpG analyses illuminate sexually dimorphic methylation of gonadal development genes with high historic methylation in turtle hatchlings with temperature-dependent sex determination

Gene

Sex of hatchlings showing hypermethylation

Hypermethylated region

Sex of stage 22 embryos showing upregulation

Amh

Female

P, I

Male

Ar

Female

P, D

Male

Gata4

Female

P, I (3)

Male

Lhx9

Female

P

Male

Sf1

Female

I

Male

Lhx1

Female

P, I (2)

–

Emx2

Male

E

–

Insr

Male

I

–

Wnt4

Male

I

–

Apc

Male

I

–

Igf1r

Male

P

–

Tcf21

Male

D

–

Six1

Female

D

–

  1. Amh, Ar, Gata4, Lhx9, Sf1 are genes upregulated at the male-producing temperature (26 °C) during stage 22 of embryonic development [42] and hypermethylated at 31 °C. All other cells denote differentially methylated genes that are not upregulated in the opposite sex
  2. P promoter, I intron, E exon, D downstream of last exon; () indicates the number of methylated windows if >1
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Epigenetics & Chromatin

ISSN: 1756-8935