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Fig. 7 | Epigenetics & Chromatin

Fig. 7

From: A computational approach for the functional classification of the epigenome

Fig. 7

Association between patterns of chromatin profiles and expression levels. a Heatmaps showing the hierarchical clustering of sets of genes with similar expression levels on the basis of the chromatin profile frequencies in a region of ±2Kb around the transcription start site. For each profile, frequencies are reported in a separate heatmap, with the corresponding color-label positioned on the top of each matrix. Each row in the matrix corresponds to a specific range of expression and is represented by all genes with an RPKM signal in that interval. Intervals are reported as ranges of percentiles derived from the RPKM distribution. Expression ranges are indicated using color-scale labels (on the left) from black (lowest) to violet (highest). In each heatmap, a region of ±2Kb around the gene TSS is reported in the columns (in 200bp bins). Each cell in the heatmap shows the logarithmic fold-change of the observed frequency over that of the random dataset. Black cells indicate a null fold-change (around 1), whilst red and blue reflect positive and negative enrichment, respectively. Unsupervised hierarchical clustering identifies five different sub-clusters that mirror well the different extent of expression. bf Average enrichment of profiles in every subcluster. Each cell in a heatmap shows the enrichment of a given profile in a given bin over the 4kb-TSS surrounding region, averaged across all genes in the subcluster. The same color-scale as in (a) is used

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