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Fig. 4 | Epigenetics & Chromatin

Fig. 4

From: A computational approach for the functional classification of the epigenome

Fig. 4

Frequency distribution of chromatin profiles around the transcription start site (TSS) and the gene middle-point (GM). The histograms plot the distribution of the different chromatin profiles around the TSS (a) and the central position of Refseq genes (b). Both distributions are generated on the basis of the observed distance (bp) of each bin to the closest TSS (corresponding to 0 on the x-axis) or GM. As shown in a, two major epigenetic profiles (ActProm and TxInit) are enriched around the promoter region of the gene. In b the genomic distances are normalized to the gene length so that the middle-point of the gene is always at the 0 position, the gene length is normalized from −50 to +50

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