Fig. 7From: Stabilization of Foxp3 expression by CRISPR-dCas9-based epigenome editing in mouse primary T cellsModel of epigenome editing in primary T cells. a dCas9-TET1CD demethylates the Foxp3 CNS2 locus and enhances Foxp3 expression weakly. b dCas9-p300CD acetylates the Foxp3 promoter locus, activates transcription in coordination with the TGF-β signal, and promotes immunosuppressive functionBack to article page