Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region

Table 3 Characteristics of four biologically and statistically significant DNA methylation sites between Nicoyans and non-Nicoyans

Probe ID	Pyrosequencing		450k array			Chr	Distance to closest TSS (bp)	Genomic region: gene	Gene ontology
Probe ID	Δβ	p value	Δβ	p value	q value	Chr	Distance to closest TSS (bp)	Genomic region: gene	Gene ontology
cg02853387	0.06	7.9E−05	0.07	1.3E−07	0.012	11	183072	Intragenic: intron 3 of DSCAML1	Protein homodimerization activity
cg02438481	0.08	1.9E−05	0.08	1.6E−07	0.012	6	−1861	Intergenic: C6orf123	–
cg13979274	0.06	9.1E−07	0.06	2.0E−07	0.012	19	4347	Intergenic: ~ 3 kb from 3′ end of OR10H1	G-protein coupled receptor/olfactory receptor activity
cg26107275	–	–	−0.07	2.2E−07	0.012	12	−407	Promoter: BC04264	–

Δβ: (Delta beta; absolute mean difference of β values between groups (Nicoyans–non-Nicoyans)
TSS Transcription start site, Chr chromosome

ISSN: 1756-8935