Table 1 Top canonical pathways after ingenuity pathway analysis of all differentially methylated region-associated genes in zebrafish larvae exposed from 0-6 days post-fertilization to mono(2-ethylhexyl) phthalate (MEHP, 30 µM) and 5-azacytidine (5AC, 10 µM)
Canonical pathway | MEHP (P value) | 5AC (P value) |
|---|---|---|
Human embryonic stem cell pluripotency | 7.36E−05 | 1.92E−05 |
Factors promoting cardiogenesis in vertebrates | 2.32E−03 | 1.32E−06 |
TGF-β signaling | 8.43E−06 | 6.28E−04 |
Wnt/β-catenin signaling | 7.10E−06 | 8.00E−04 |
Axonal guidance signaling | 2.68E−03 | 1.05E−05 |
Regulation of the epithelial–mesenchymal transition pathway | 1.87E−05 | 4.91E−03 |
Gα12/13 signaling | 3.59E−06 | 4.21E−02 |
Adipogenesis pathway | 5.23E−03 | 1.17E−03 |
Role of NANOG in mammalian embryonic stem cell pluripotency | 6.56E−03 | 9.54E−04 |
Epithelial adherent junction signaling | 6.66E−04 | 1.93E−02 |