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Fig. 2 | Epigenetics & Chromatin

Fig. 2

From: Links between DNA methylation and nucleosome occupancy in the human genome

Fig. 2

Average DNA methylation levels and nucleosome occupancy as a function of nucleosome core CpG frequency. Nucleosome sublibraries were generated for the in vitro and in vivo leukocyte and IMR90 MNase-seq libraries based on the number of CpG occurrences between positions −61 to +61 relative to nucleosome midpoints. Using BS-seq and MNase-seq data from leukocytes, average mCpG/CpG fractions were computed from forward and reverse complement sequences aligned to nucleosome midpoints for each in vitro (a) and in vivo (b) nucleosome sublibrary. Using MNase-seq and NOMe-seq data from IMR90 cells, average mHCG/HCG fractions (c) and uGCH/GCH fractions (d) were computed from forward and reverse complement sequences aligned to MNase-seq derived nucleosome midpoints for each nucleosome sublibrary. Nucleosomes within CpG Islands were excluded from this analysis

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