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Fig. 2 | Epigenetics & Chromatin

Fig. 2

From: Internal modifications in the CENP-A nucleosome modulate centromeric dynamics

Fig. 2

Global compaction of the histone core disrupts CENP-C binding. a Contact analysis of the H2A to H2A′ interface on the opposite face of the nucleosome from the acetylations studied. The contact cutoff between Cα atoms was set to 8 Å. A value of 1, white, shows a contact formed over all simulation time steps and 0, black, never. An increase in contacts is shown upon acetylation consistent with a global compaction of the histone core transduced away from the points of acetylation. b To study the effects of the histone core compaction with acetylation, the CENP-C fragment [27] was docked to the nucleosomes and contacts analyzed. The CENP-C fragment is shown to form stable contacts with the CENP-A C-terminal end that are lost upon acetylation

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