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Fig. 2 | Epigenetics & Chromatin

Fig. 2

From: Identification of epigenetic signature associated with alpha thalassemia/mental retardation X-linked syndrome

Fig. 2

Methylation visualization of significantly altered genes ZNF300P1 (a) and CD47 (b) in ATR-X patients (red) and controls (blue) identified by methylation array (top images) and bisulfite mutagenesis sequencing (bottom images). Top and bottom images show the same genomic coordinates. Methylation array figures were generated using Genomic Browser viewer (Partek) and shows methylation level 0 (not methylated) to 1 (100% methylated). CpG island and gene location and chromosome coordinates are also represented. The bottom image corresponds to methylation average based on bisulfite sequencing data from two ATR-X patients and two controls across the same regions from the top image. Bisulfite mutagenesis and sequencing analysis of these regions confirms effects seen by methylation array analysis

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Epigenetics & Chromatin

ISSN: 1756-8935