Histone peptide microarray screen of chromo and Tudor domains defines new histone lysine methylation interactions

Table 1 Summary of reader domain interactions identified via histone peptide microarrays

Protein	Domain	Top array hits	Known interactions	References
HP1β/CBX1	Chromo	H3K9me1/2/3, H3K23me1/2/3	H3K9me1/2/3, H3K23me1/2/3	[21, 22, 46, 52]
HP1γ/CBX3	Chromo	H3K9me1/2/3, H3K23me3 ^a	H3K9me2/3	[21, 22, 52, 74]
HP1α/CBX5	Chromo	H3K9me1/2/3, H3K23me3 ^a	H3K9me1/2/3	[21, 48, 52]
CDYL1b	Chromo	H3K9me1/2/3, H3K27me2/3	H3K9me1/2/3, H3K27me1/2/3	[75]
CDYL2	Chromo	H3K9me2/3, H3K27me3	H3K9me1/2/3, H3K27me1/2/3	[76]
CHD1	Chromo (2)	H3K4me2/3	H3K4me3	[54, 55]
CHD7	Chromo (2)	H4me0	H3K4me1/2/3	[56]
CHD9	Chromo (2)	H4me0
MPP8	Chromo	H3K9me1/2/3, H3K23me2/3	H3K9me1/2/3, H3K23me1/2/3	[46, 77, 78]
53BP1	Tudor (2)	H3K4me2, H3K18me2^a, H3K36me2^a, H4K20me1/2	H3K4me2, H4K20me1/2	[42, 52]
JMJD2A	Tudor (2)	H3K4me2/3, H3K18me3^a, H3K9me3, H4K20me2/3	H3K4me3, H4K20me2/3	[51, 52]
PHF20	Tudor (2)	H3K9me2/3, H4K8me1	H3K9me2, H3K27me2, H3K36me2	[35]
UHRF1	Tudor-like	H3K9me2/3	H3K9me2/3	[79, 80]
PHF1	Tudor	H3K36me3	H3K36me2/3	[81,82,83,84]
SGF29	Double Tudor	H3K4me3	H3K4me1/2/3	[85]
SPIN1	Triple Tudor	H3K4me2/3, H3K18me3, H4K20me3 ^a	H3K4me2/3	[40]
TDRD2	Tudor (extended)	H3K4me3
TDRD3	Tudor	H3R2me2a, H3R8me2a	pan-Rme2a	[53]
GLP	ANK	H3K9me1/2	H3K9me1/2	[86]
ING2	PHD	H3K4me2/3	H3K4me2/3	[87, 88]
TAF3	PHD	H3K4me2/3	H3K4me2/3	[89]
L3MBTL1	MBT (3)	H3K4me2, H3K9me2, H4K8me1	H3K4me1/2, H3K9me1/2, H3K27me1/2, H4K20me1/2	[90,91,92]