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Table 1 Summary of reader domain interactions identified via histone peptide microarrays

From: Histone peptide microarray screen of chromo and Tudor domains defines new histone lysine methylation interactions

Protein Domain Top array hits Known interactions References
HP1β/CBX1 Chromo H3K9me1/2/3, H3K23me1/2/3 H3K9me1/2/3, H3K23me1/2/3 [21, 22, 46, 52]
HP1γ/CBX3 Chromo H3K9me1/2/3, H3K23me3 a H3K9me2/3 [21, 22, 52, 74]
HP1α/CBX5 Chromo H3K9me1/2/3, H3K23me3 a H3K9me1/2/3 [21, 48, 52]
CDYL1b Chromo H3K9me1/2/3, H3K27me2/3 H3K9me1/2/3, H3K27me1/2/3 [75]
CDYL2 Chromo H3K9me2/3, H3K27me3 H3K9me1/2/3, H3K27me1/2/3 [76]
CHD1 Chromo (2) H3K4me2/3 H3K4me3 [54, 55]
CHD7 Chromo (2) H4me0 H3K4me1/2/3 [56]
CHD9 Chromo (2) H4me0   
MPP8 Chromo H3K9me1/2/3, H3K23me2/3 H3K9me1/2/3, H3K23me1/2/3 [46, 77, 78]
53BP1 Tudor (2) H3K4me2, H3K18me2a, H3K36me2a, H4K20me1/2 H3K4me2, H4K20me1/2 [42, 52]
JMJD2A Tudor (2) H3K4me2/3, H3K18me3a, H3K9me3, H4K20me2/3 H3K4me3, H4K20me2/3 [51, 52]
PHF20 Tudor (2) H3K9me2/3, H4K8me1 H3K9me2, H3K27me2, H3K36me2 [35]
UHRF1 Tudor-like H3K9me2/3 H3K9me2/3 [79, 80]
PHF1 Tudor H3K36me3 H3K36me2/3 [81,82,83,84]
SGF29 Double Tudor H3K4me3 H3K4me1/2/3 [85]
SPIN1 Triple Tudor H3K4me2/3, H3K18me3, H4K20me3 a H3K4me2/3 [40]
TDRD2 Tudor (extended) H3K4me3   
TDRD3 Tudor H3R2me2a, H3R8me2a pan-Rme2a [53]
GLP ANK H3K9me1/2 H3K9me1/2 [86]
ING2 PHD H3K4me2/3 H3K4me2/3 [87, 88]
TAF3 PHD H3K4me2/3 H3K4me2/3 [89]
L3MBTL1 MBT (3) H3K4me2, H3K9me2, H4K8me1 H3K4me1/2, H3K9me1/2, H3K27me1/2, H4K20me1/2 [90,91,92]
  1. Italics, validated by peptide pull-down assays
  2. aNovel interactions