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Fig. 9 | Epigenetics & Chromatin

Fig. 9

From: PRC2 is required for extensive reorganization of H3K27me3 during epigenetic reprogramming in mouse fetal germ cells

Fig. 9

Blockage of EZH1/2 significantly reduces H3K27me3 enrichment near the nuclear lamina in fetal germ cells undergoing epigenetic reprogramming. Radial histogram quantification of dSTORM super-resolution immunofluorescent images of sections from E11.5 fetal testes and ovaries cultured for 48 h. E11.5 wild-type control is shown in green, E11.5 + 48 h vehicle control (DMSO) is shown in blue, and E11.5 + 48 h of GSK126 treatment (10 μm) shown in red. Left image of each colored panel (×160) represents merged channels, with green marking germ cells (eGFP) and H3K27me3 shown in the red channel. 10 μm scale bars. The right-hand image of each panel shows dSTORM super-resolution images of germ cells (H3K27me3 in grayscale). 1 μm scale bars. 3–8 super-resolved images from three biological replicates. Y-axis shows relative H3K27me3 intensity, and X-axis shows radial distance (μm) from the center of the nucleus. Error bars ± SEM

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