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Fig. 4 | Epigenetics & Chromatin

Fig. 4

From: Protein kinase Msk1 physically and functionally interacts with the KMT2A/MLL1 methyltransferase complex and contributes to the regulation of multiple target genes

Fig. 4

Effect of KMT2A/MLL1 or Msk1 knockdown on H3K4me3, H3K9acS10ph and H3K27me3 distribution across HoxA4 and HoxA5. a Effect of KMT2A/MLL1 or Msk1 knockdown on H3K4me3, H3K9acS10ph and H3K27me3 levels at HoxA4 (upper panels) and HoxA5 (lower panels). Histograms present the modification abundance at these sites as a bound/unbound ratio, where 1.0 indicates there is no enrichment (n = 1 or 2, T test, *p < 0.05; **p < 0.01). b Proposed model of how the KMT2A/MLL1 and Msk1 interaction within the KMT2A/MLL1 complex facilitates H3K4 methylation at transcription start sites (TSSs). Msk1-catalysed H3S10 phosphorylation directly enhances KMT2A/MLL1-catalysed H3K4 methylation and, potentially, improves access of the complex to condensed chromatin by reversing chromatin compaction

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