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Table 3 Sensitivity and specificity data for histone modifications associated with open chromatin

From: Systematic comparison of monoclonal versus polyclonal antibodies for mapping histone modifications by ChIP-seq

 

Specificity

Sensitivity

Mono (%)

Poly (%)

Mono (%)

Poly (%)

H3K27ac

89

85

68

69

H3K4me1

38

36

54

59

H3K4me3

91

90

86

87

  1. Sensitivity and specificity of monoclonal and polyclonal antibodies. Specificity is calculated as the percentage of the genomic bases that are identified as peaks that are within the expected canonical genomic region, as annotated by ENCODE. Sensitivity is calculated at the percentage of bases within the expected genomic region that are identified as being within peaks. Only genomic bases annotated in the ENCODE segmentation tracks for K562 are included in this calculation