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Fig. 1 | Epigenetics & Chromatin

Fig. 1

From: Histone macroH2A1.2 promotes metabolic health and leanness by inhibiting adipogenesis

Fig. 1

Expression of macroH2A1 isoforms in human and mouse adipose tissue. a Left panel representative immunoblots of visceral adipose tissue (VAT) human biopsies from subjects with increasing BMI (25, 26, 27, 28, 30, 40), using antibodies against macroH2A1.1, macroH2A1.2 and H3. Right panel densitometric quantification of macroH2A1.1 levels normalized to H3 loading control as in the left panel, expressed as arbitrary units. b Left representative confocal images of adipose tissue sections immunolabelled for macroH2A1.1 or macroH2A1.2. MacroH2A1.1 (left panel, green) is highly expressed in mouse adipocytes, and higher magnification inset shows its subcellular localization in macrochromatin bodies and overlapping signals with DAPI (red) are shown in yellow. MacroH2A1.2 (right panel, green) appears not expressed in mice adipose tissue. Scale Bars 10 μm. Right representative immunoblots of visceral adipose tissue from three wild-type mice, using antibodies against macroH2A1.1, macroH2A1.2 and H3

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