Fig. 3

LET-418 associates with chromatin genome-wide and is enriched proximally to the TSS. a Genome-wide ChIP-Seq binding profile of embryonic LET-418::3xFLAG (red lines), compared with non-enriched input DNA (gray). Red bars below: LET-418 most enriched sites (MACS2 peaks). Scale 0–163 (composite value). b, c Ngsplot of LET-418 genome-wide enrichment centered on the transcription start site (TSS) (b), or on the gene body between TSS and TES (c). Input DNA profile is represented in gray for comparison. Ngsplot profiles were calculated for the entire coding-gene population, or only for the list of LET-418 enriched (peaks) or non-enriched genes. Y axis: read count per million mapped reads