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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3

Fig. 3

Histone methylation profiles at genic regions during hypoxia. a Bar graph depicting numbers of H3K4me3-associated genes under indicated conditions (normoxia: 0 h, acute hypoxia: 8 h; chronic hypoxia: 24 h; reoxygenation: +8 h); b H3K4me3 peak intensity density distribution proximal to the TSS in relation to oxygen deprivation and reoxygenation; c Boxplots representing median gene expression in relation to H3K4me3 marking. d Bar graph depicting numbers of H3K27me3-associated genes; e H3K27me3 distribution proximal to the TSS in relation to oxygen deprivation and reoxygenation; f Boxplots representing median gene expression in relation to H3K27me3 marking. Data presented reflect indicated conditions (normoxia: 0 h, acute hypoxia: 8 h; chronic hypoxia: 24 h; reoxygenation: +8 h). Asterisks (c, f) indicate statistically significant differences (p < 0.05)

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