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Table 1 Meta-analysis of age-related DNMT and TET expression in brain

From: Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice

Entrez ID Symbol Chr Name Coeff. SE t p value
80312 TET1 10 Tet methylcytosine dioxygenase 1 −0.00192 0.006 −0.34 0.73
54790 TET2 4 Tet methylcytosine dioxygenase 2 −0.00002 0.005 −0.004 1.0
200424 TET3 2 Tet methylcytosine dioxygenase 3 −0.00033 0.005 −0.064 0.95
1786 DNMT1 19 DNA (cytosine-5-)-methyltransferase 1 0.00784 0.007 1.093 0.27
1788 DNMT3a 2 DNA (cytosine-5-)-methyltransferase 3 alpha 0.004 0.004 0.980 0.33
1789 DNMT3b 20 DNA (cytosine-5-)-methyltransferase 1 −0.00009 0.004 -0.02 0.98
  1. To test whether the expression levels of these genes change with age, we used a linear mixed-effects (lme4) model: [GeneExpression ~ Age: TissueID + (1|ExperimentID) + (1|PlatformID)]. Shown above is the age–tissue interaction term for brain. “Coef” describes the estimated coefficient of the change in Z-score per year for the expression of each gene, the standard error (SE), and t-statistic for the analysis. The p value shows that none of the estimated gene expression changes with age are statistically significant