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Fig. 6 | Epigenetics & Chromatin

Fig. 6

From: Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice

Fig. 6

Global mC levels: ELISA and pyrosequencing. a Total/global levels of hippocampal mC were analyzed by ELISA with synthetic methylation standards (young, adult, and old, females and males Set 1). (*p < 0.05 Student–Newman–Keuls pairwise post hoc test following two-way ANOVA). b Using a mouse whole-genome methylation standard curve, the Set 2 samples (young and old, females and males) were analyzed by mC ELISA. Repeat element methylation was analyzed by pyrosequencing of the c B1 element and the d LINE1 repeat (young and old, females and males Set 2). No differences were evident in any of the individual CG sites or in the mean of the element

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