Fig. 4
From: Chromatin variation associated with liver metabolism is mediated by transposable elements
Specific TFs bind to younger and older LINEs. a Top known motifs found in variable chromatin sites overlapping older (top) or younger (bottom) LINEs. Numbers in parentheses represent p-values of enrichment of motif occurrence in the given set of sequences compared with background, and the percentage of sequences with the motif. b Age distribution of all LINEs as well as LINEs containing HNF4α ChIP-seq peaks. Myrs million years. c Percentage of older-LINE-associated variable sites bound by liver TFs (HNF4α and C/EBPα) or CTCF (**indicates p < 0.001, Fisher’s exact test). d Age distribution of all LINEs as well as LINEs containing STAT or HNF4α motif within accessible chromatin sites in C57BL/6J mouse liver. e Genome browser view of an L1Md_F2 located upstream of Ugt2b37. The GAS motif site is overlapping a site that is accessible in C57BL/6J but not C3H/HeJ. The 170-mer mappability tracks for the reference genome and the C3H/HeJ pseudo-genome are shown below. f Mean relative value of STAT3 ChIP-qPCR compared to IgG control of liver samples from C57BL/6J or C3H/HeJ mice. Error bars represent the SEM (n = 3)