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Table 6 Top 30 gene-annotated differentially methylated regions associated with FASD

From: DNA methylation signature of human fetal alcohol spectrum disorder

Gene symbol(s) DMR location Chr Start position End position # of probes Min FDR Mean FDR Max beta FCa
HLA-DPB1 Body 6 33047056 33049505 17 2.59E−50 1.61E−06 0.087
SLC22A18, SLC22A18AS Body, TSS1500, TSS200, 5′ UTR 11 2919689 2921176 20 1.21E−29 1.46E−05 −0.049
PPP1R2P1 Body 6 32846924 32847845 18 1.81E−20 9.39E−10 0.026
SLC38A2 TSS1500 12 46767132 46768016 8 1.98E−16 9.78E−09 −0.039
HKR1 TSS1500, TSS200, 1st exon, 5′ UTR 19 37825307 37825679 7 7.51E−16 9.51E−16 0.022
WDR52 5′ UTR, 1st exon, TSS200, TSS1500 3 113160071 113160821 10 1.34E−14 6.02E−13 −0.037
C3orf24 5′ UTR, 1st exon, TSS200, TSS1500 3 10149466 10150487 11 4.41E−13 1.88E−11 0.034
NOS1AP Body, 3′ UTR 1 162336877 162337375 5 4.69E−13 8.79E−13 0.039
KCNAB2 5′ UTR 1 6093770 6094993 6 9.78E−13 2.86E−07 0.026
F7 TSS1500, TSS200, Body 13 113759771 113760286 6 1.55E−10 1.96E−10 0.029
IFT140, TMEM204 Body 16 1598866 1599150 4 1.81E−10 4.34E−10 −0.036
RGL3 Body 19 11517079 11517436 4 3.06E−10 5.34E−10 0.036
STRA6 5′ UTR, 1st exon, TSS200, TSS1500 15 74494781 74496040 12 4.80E−10 1.06E−04 0.035
TXNRD1, EID3 5′ UTR, Body, TSS1500, TSS200, 1st exon 12 104697193 104697983 11 5.49E−10 3.98E−08 0.024
RNMTL1 Body, 3′ UTR 17 695156 695661 3 5.77E−10 3.23E−09 −0.026
C22orf42 Body, TSS200 22 32554848 32555310 5 7.95E−10 7.91E−09 0.022
RADIL Body 7 4869981 4870162 3 2.40E−09 2.48E−09 0.026
ITGAL Body 16 30485383 30485966 6 7.18E−09 5.13E−08 0.022
ZNF710 5′ UTR 15 90547692 90548043 3 4.18E−08 5.44E−07 −0.023
PCDHA7, PCDHAC2, PCDHA12, PCDHA6, PCDHA10, PCDHA4, PCDHA11, PCDHA8, PCDHA1, PCDHA2, PCDHA9, PCDHA13, PCDHA5, PCDHAC1, PCDHA3 Body, TSS1500 5 140344290 140344745 4 4.73E−08 1.20E−07 0.019
MAL2 TSS200, 1st exon, body 8 120220410 120221797 8 1.26E−07 2.35E−03 −0.022
UCN3 TSS1500, TSS200, 1st exon, 5′ UTR 10 5406543 5407020 8 1.32E−07 3.03E−07 0.016
HKDC1 TSS1500, 5′ UTR, 1st exon 10 70979777 70980067 4 1.37E−07 1.40E−07 0.023
ARHGEF19 Body 1 16533422 16534579 8 1.88E−07 1.11E−04 −0.035
LOC154822 Body 7 158815555 158816392 3 2.36E−07 1.90E−05 −0.043
NDST4 1st exon, 5′ UTR, TSS200, TSS1500 4 116034871 116035232 4 5.96E−07 6.45E−07 0.031
SNED1 Body 2 242009513 242009588 2 6.41E−07 6.48E−07 0.040
PRKDC Body 8 48739161 48739256 2 7.94E−07 8.04E−07 −0.045
CASZ1 5′ UTR 1 10847541 10847594 2 2.92E−06 2.92E−06 0.025
HEATR2 Body 7 807596 809109 9 3.11E−06 3.69E−04 0.036
  1. aMax fold changes (FC) represented in percent methylation change (beta) in DNA methylation levels of FASD compared to control