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Table 6 Top 30 gene-annotated differentially methylated regions associated with FASD

From: DNA methylation signature of human fetal alcohol spectrum disorder

Gene symbol(s)

DMR location

Chr

Start position

End position

# of probes

Min FDR

Mean FDR

Max beta FCa

HLA-DPB1

Body

6

33047056

33049505

17

2.59E−50

1.61E−06

0.087

SLC22A18, SLC22A18AS

Body, TSS1500, TSS200, 5′ UTR

11

2919689

2921176

20

1.21E−29

1.46E−05

−0.049

PPP1R2P1

Body

6

32846924

32847845

18

1.81E−20

9.39E−10

0.026

SLC38A2

TSS1500

12

46767132

46768016

8

1.98E−16

9.78E−09

−0.039

HKR1

TSS1500, TSS200, 1st exon, 5′ UTR

19

37825307

37825679

7

7.51E−16

9.51E−16

0.022

WDR52

5′ UTR, 1st exon, TSS200, TSS1500

3

113160071

113160821

10

1.34E−14

6.02E−13

−0.037

C3orf24

5′ UTR, 1st exon, TSS200, TSS1500

3

10149466

10150487

11

4.41E−13

1.88E−11

0.034

NOS1AP

Body, 3′ UTR

1

162336877

162337375

5

4.69E−13

8.79E−13

0.039

KCNAB2

5′ UTR

1

6093770

6094993

6

9.78E−13

2.86E−07

0.026

F7

TSS1500, TSS200, Body

13

113759771

113760286

6

1.55E−10

1.96E−10

0.029

IFT140, TMEM204

Body

16

1598866

1599150

4

1.81E−10

4.34E−10

−0.036

RGL3

Body

19

11517079

11517436

4

3.06E−10

5.34E−10

0.036

STRA6

5′ UTR, 1st exon, TSS200, TSS1500

15

74494781

74496040

12

4.80E−10

1.06E−04

0.035

TXNRD1, EID3

5′ UTR, Body, TSS1500, TSS200, 1st exon

12

104697193

104697983

11

5.49E−10

3.98E−08

0.024

RNMTL1

Body, 3′ UTR

17

695156

695661

3

5.77E−10

3.23E−09

−0.026

C22orf42

Body, TSS200

22

32554848

32555310

5

7.95E−10

7.91E−09

0.022

RADIL

Body

7

4869981

4870162

3

2.40E−09

2.48E−09

0.026

ITGAL

Body

16

30485383

30485966

6

7.18E−09

5.13E−08

0.022

ZNF710

5′ UTR

15

90547692

90548043

3

4.18E−08

5.44E−07

−0.023

PCDHA7, PCDHAC2, PCDHA12, PCDHA6, PCDHA10, PCDHA4, PCDHA11, PCDHA8, PCDHA1, PCDHA2, PCDHA9, PCDHA13, PCDHA5, PCDHAC1, PCDHA3

Body, TSS1500

5

140344290

140344745

4

4.73E−08

1.20E−07

0.019

MAL2

TSS200, 1st exon, body

8

120220410

120221797

8

1.26E−07

2.35E−03

−0.022

UCN3

TSS1500, TSS200, 1st exon, 5′ UTR

10

5406543

5407020

8

1.32E−07

3.03E−07

0.016

HKDC1

TSS1500, 5′ UTR, 1st exon

10

70979777

70980067

4

1.37E−07

1.40E−07

0.023

ARHGEF19

Body

1

16533422

16534579

8

1.88E−07

1.11E−04

−0.035

LOC154822

Body

7

158815555

158816392

3

2.36E−07

1.90E−05

−0.043

NDST4

1st exon, 5′ UTR, TSS200, TSS1500

4

116034871

116035232

4

5.96E−07

6.45E−07

0.031

SNED1

Body

2

242009513

242009588

2

6.41E−07

6.48E−07

0.040

PRKDC

Body

8

48739161

48739256

2

7.94E−07

8.04E−07

−0.045

CASZ1

5′ UTR

1

10847541

10847594

2

2.92E−06

2.92E−06

0.025

HEATR2

Body

7

807596

809109

9

3.11E−06

3.69E−04

0.036

  1. aMax fold changes (FC) represented in percent methylation change (beta) in DNA methylation levels of FASD compared to control
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Epigenetics & Chromatin

ISSN: 1756-8935