Table 5 Disease association enrichment in genes up-methylated in FASD
From: DNA methylation signature of human fetal alcohol spectrum disorder
Disease name | Disease ID | p-value | FDR | Genes |
|---|---|---|---|---|
Anxiety disorder | DOID_2030 | 1.44E−04 | 0.071 | CRHR2, CYP3A4, GRM8, NOS1AP, P2RX7, PAM, SHANK1, SLC6A3 |
Pervasive developmental disorder | DOID_0060040 | 1.15E−04 | 0.076 | AGAP1, ARID1B, ATP2B2, ATP10A, CDH10, DCUN1D1, DPP6, ESRRB, GABRB1, GRM8, HEPACAM, NOS1AP, NRXN1, PCDHAC2, ROBO3, SDK1, SHANK1, SHANK3, SLC6A3, ST8SIA2 |
Epilepsy syndrome | DOID_1826 | 2.07E−04 | 0.081 | BRD2, CACNA1A, CCR3, CIT, GJD2, GRM1, GRM8, KCNAB2, NRXN1, NTNG2, P2RX7, PAM, SLC6A1, SLC6A3, SLC8A1 |
Autistic disorder | DOID_12849 | 4.70E−05 | 0.092 | AGAP1, ATP10A, CDH10, GABRB1, GRM8, HEPACAM, NOS1AP, NRXN1, ROBO3, SHANK1, SHANK3, ST8SIA2 |
Autism spectrum disorder | DOID_0060041 | 1.01E−04 | 0.099 | AGAP1, ARID1B, ATP2B2, ATP10A, CDH10, DCUN1D1, DPP6, ESRRB, GABRB1, GRM8, HEPACAM, NOS1AP, NRXN1, PCDHAC2, ROBO3, SDK1, SHANK1, SHANK3, SLC6A3, ST8SIA2 |
Substance-related disorder | DOID_303 | 6.85E−04 | 0.192 | ADARB2, ANPEP, CACNA1A, CDH13, CRHR2, FRMD4A, GRM8, KCND3, KISS1R, NMU, NRXN1, SLC6A1, SLC6A3, TIAM2, TRPM4 |