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Table 5 Disease association enrichment in genes up-methylated in FASD

From: DNA methylation signature of human fetal alcohol spectrum disorder

Disease name Disease ID p-value FDR Genes
Anxiety disorder DOID_2030 1.44E−04 0.071 CRHR2, CYP3A4, GRM8, NOS1AP, P2RX7, PAM, SHANK1, SLC6A3
Pervasive developmental disorder DOID_0060040 1.15E−04 0.076 AGAP1, ARID1B, ATP2B2, ATP10A, CDH10, DCUN1D1, DPP6, ESRRB, GABRB1, GRM8, HEPACAM, NOS1AP, NRXN1, PCDHAC2, ROBO3, SDK1, SHANK1, SHANK3, SLC6A3, ST8SIA2
Epilepsy syndrome DOID_1826 2.07E−04 0.081 BRD2, CACNA1A, CCR3, CIT, GJD2, GRM1, GRM8, KCNAB2, NRXN1, NTNG2, P2RX7, PAM, SLC6A1, SLC6A3, SLC8A1
Autistic disorder DOID_12849 4.70E−05 0.092 AGAP1, ATP10A, CDH10, GABRB1, GRM8, HEPACAM, NOS1AP, NRXN1, ROBO3, SHANK1, SHANK3, ST8SIA2
Autism spectrum disorder DOID_0060041 1.01E−04 0.099 AGAP1, ARID1B, ATP2B2, ATP10A, CDH10, DCUN1D1, DPP6, ESRRB, GABRB1, GRM8, HEPACAM, NOS1AP, NRXN1, PCDHAC2, ROBO3, SDK1, SHANK1, SHANK3, SLC6A3, ST8SIA2
Substance-related disorder DOID_303 6.85E−04 0.192 ADARB2, ANPEP, CACNA1A, CDH13, CRHR2, FRMD4A, GRM8, KCND3, KISS1R, NMU, NRXN1, SLC6A1, SLC6A3, TIAM2, TRPM4