Table 2 Gene ontology analysis of MeCP2 bound promoters
From: Genome-wide redistribution of MeCP2 in dorsal root ganglia after peripheral nerve injury
| GO term | p value | q value FDR B&H | Hit count in query list | GO accession |
|---|---|---|---|---|
| Molecular function | ||||
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | 2.09E−09 | 6.41E−06 | 214 | GO:0000981 |
| Transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | 7.30E−08 | 1.12E−04 | 125 | GO:0001228 |
| Transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding | 1.13E−07 | 1.16E−04 | 126 | GO:0000982 |
| Enzyme binding | 3.44E−06 | 2.12E−03 | 500 | GO:0019899 |
| Regulatory region DNA binding | 3.82E−06 | 2.12E−03 | 247 | GO:0000975 |
| Transcription regulatory region DNA binding | 4.16E−06 | 2.12E−03 | 246 | GO:0044212 |
| Regulatory region nucleic acid binding | 5.08E−06 | 2.23E−03 | 247 | GO:0001067 |
| Receptor binding | 1.94E−05 | 5.74E−03 | 427 | GO:0005102 |
| Sequence-specific double-stranded DNA binding | 2.10E−05 | 5.74E−03 | 211 | GO:1990837 |
| Double-stranded DNA binding | 2.15E−05 | 5.74E−03 | 233 | GO:0003690 |
| Biological process | ||||
| Tissue development | 7.05E−18 | 7.67E−14 | 595 | GO:0009888 |
| Skeletal system development | 5.71E−17 | 3.11E−13 | 203 | GO:0001501 |
| Organ morphogenesis | 9.09E−16 | 3.30E−12 | 345 | GO:0009887 |
| Regulation of multicellular organismal | 3.00E−15 | 7.71E−12 | 541 | GO:2000026 |
| Regulation of cell differentiation | 3.54E−15 | 7.71E−12 | 509 | GO:0045595 |
| Regulation of nervous system development | 6.60E−15 | 1.20E−11 | 292 | GO:0051960 |
| Neurogenesis | 8.78E−15 | 1.37E−11 | 557 | GO:0022008 |
| Regulation of cell development | 4.71E−14 | 6.42E−11 | 316 | GO:0060284 |
| Generation of neurons | 1.11E−13 | 1.34E−10 | 528 | GO:0048699 |
| Positive regulation of cell differentiation | 3.12E−13 | 3.28E−10 | 309 | GO:0045597 |
| Cellular component | ||||
| Neuron projection | 2.19E−08 | 2.77E−05 | 333 | GO:0043005 |
| Neuron part | 1.99E−07 | 1.26E−04 | 409 | GO:0097458 |
| Somatodendritic compartment | 1.93E−06 | 8.17E−04 | 246 | GO:0036477 |
| Cell body | 8.24E−06 | 1.86E−03 | 197 | GO:0044297 |
| Integral component of plasma membrane | 8.41E−06 | 1.86E−03 | 427 | GO:0005887 |
| Neuronal cell body | 8.81E−06 | 1.86E−03 | 178 | GO:0043025 |
| Anchoring junction | 1.21E−05 | 2.19E−03 | 152 | GO:0070161 |
| Intrinsic component of plasma membrane | 1.66E−05 | 2.63E−03 | 440 | GO:0031226 |
| Potassium channel complex | 2.10E−05 | 2.96E−03 | 38 | GO:0034705 |
| Adherens junction | 3.00E−05 | 3.80E−03 | 145 | GO:0005912 |