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Fig. 4 | Epigenetics & Chromatin

Fig. 4

From: Genome-wide redistribution of MeCP2 in dorsal root ganglia after peripheral nerve injury

Fig. 4

miR-126 locus has enriched MeCP2 binding in SNI model. a MeCP2 peak profile from ChIP-seq at miR-126a/miR-126b shows enrichment of MeCP2 binding to miR-126 locus in the SNI model, and virtually no binding in the sham control. b CpG methylation of miR-126 locus was identical in SNI and sham control mice. Bisulfite sequencing of the 72-bp sequence of premiR-126 locus harboring 6 CpG sites using DRG genomic DNA obtained from SNI and sham control mice showed methylation of all CpG sites in both SNI and sham samples (n = 3). Identical methylation pattern in SNI and sham control indicates that SNI does not alter the methylation pattern of premiR-126 locus

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