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Fig. 4 | Epigenetics & Chromatin

Fig. 4

From: Abnormal X chromosome inactivation and sex-specific gene dysregulation after ablation of FBXL10

Fig. 4

Dysregulation of X-linked genes in female but not male Fbxl10 T/T embryos. a Transcripts from X-linked genes were computationally isolated from RNA-seq data and expression levels compared to E9.5 Fbxl10 T/T versus Fbxl10 +/+ embryos. b Histogram analysis of the RNA-seq data in a. Both autosomal and X-linked genes are dysregulated in female Fbxl10 T/T embryos, but X-linked genes are more severely affected and a greater extent of downregulation is apparent. c Downregulation of X-linked genes in female Fbxl10 T/T embryos is of high statistical significance

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