|
Row #
|
Cell line
|
# of All origins
|
# Shared origins
|
# of Cell-specific origins
|
% Shared
|
% Cell specific
|
|---|
|
1
|
ES
|
90,621
|
62,477
|
8507
|
68.9
|
9.4
|
|
2
|
EB
|
144,753
|
65,868
|
18,366
|
45.5
|
12.7
|
|
3
|
AS_iPS
|
119,944
|
67,977
|
14,896
|
56.7
|
12.4
|
|
4
|
PWS_iPS
|
135,397
|
76,642
|
16,471
|
56.6
|
12.2
|
|
5
|
K562
|
202,653
|
64,972
|
35,266
|
32.1
|
17.4
|
|
6
|
MCF7
|
193,118
|
62,930
|
26,100
|
32.6
|
13.5
|
|
7
|
HCT116
|
78,859
|
57,873
|
1319
|
73.4
|
1.7
|
|
8
|
U2OS
|
92,814
|
60,631
|
3955
|
65.3
|
4.3
|
- Replication origins were identified as regions enriched in nascent strand reads in four non-cancer cell lines (ES, EB, AS_iPS and PWS_iPS) and in four cancer cell lines (K562, MCF7, HCT116, U2OS). The number of replication origins is the number of origin peaks called versus the appropriate genomic control for each cell line (see “Methods” section and Additional file 1 for details and reproducibility data). The number of shared origins is the number of origin peaks that were present in the indicated cell line and in all other cells of the same group (non-cancer cells for ES, EB and the two iPS lines and cancer cells for K562, MCF7, HCT116 and U2OS). The number of cell-specific origins is the number of origin peaks that were present in the reference cell line, but not in any of the other cells of the same group. The “% shared” peaks and the “% cell-specific” peaks represent the percentage of shared and cell-specific peaks, respectively, versus the overall number of peaks in the indicated file
