Fig. 7

Association of subsets of EB replication origins with annotated genomic domains. Subsets of EB replication origins (all origins, shared origins and cell-type-specific origins) were stratified based on replication timing and investigated for their association with K562 genomic domains using SAGA analysis [56]. For each subgroup, the extent of enrichment for a particular domain is indicated on the scale of color bar. Repressive domains include constitutive heterochromatin (CON), facultative heterochromatin (FAC) and quiescent domains (QUI). Active domains include broad expression domains (BRD) and specific expression domains (SPC). The groups designated “early,” “late” and “middle” represent all origins stratified by replication time (during S-phase). The “none” group corresponds to all non-origin positions