Fig. 6

Shared and cell-type-specific replication origins clustered by association with chromatin features. Alignment of origins with chromatin modifications was performed using ColoWeb [48] as exemplified in Fig. 4. Heat maps representing the extent of preferential association of origins with distinct chromatin modifications were clustered by chromatin modifications and cell lines. The extent of association between origins and each modification is color coded, with deeper red color representing higher mean-centered AMI values and blue representing lower values. Shared and cell-type-specific replication origins clustered separately and displayed distinct associations with chromatin modifications