Fig. 1

A recurrent group of shared replication origins in normal and cancer cells. The numbers of shared replication origins among a normal and b cancer cells. For each cell line, the overall number of origin peaks is plotted in the top column followed by the number of origins in that cell line that were also present in the other cells indicated (sequential intersections; for details, see “Methods” section and Table 1 and Additional file 1: S2a–c). For example, in panel a, top group, EB represents the number of origin peaks present in the EB sample; EB + ES depicts the number of origin peaks present in the EB sample that were also present in the ES sample; EB + ES + AS depicts the number of origin peaks present in the EB sample that were also present in the ES and the AS samples, etc. The last column for each cell line group shows the number of origins remaining following sequential intersections with a all four normal cell lines or b all four cancer cell lines. Normal cell lines were AS (AS_IPS), PWS (PWS_IPS), ES (H1ES) and EB. Cancer cell lines were K562 (K), MCF7 (M), HCT116 (H) and U2OS (U)