Fig. 3

a The ChIP-seq tag densities of Rad21 were compared at genomic sites occupied with (red) or without (green) Wapal in a 2.5 kb window around peak center. b ChIP-seq tag densities for each Rad21 binding site within the genome is visualized as individual rows, with the color scale indicating a relative linear gradient from 0 to maximal (100 %) tag values. Two different plots were generated based upon the binding with (left) or without (right) Wapal. Row order is from lowest binding to highest binding. c Wapal was depleted with two, independent shRNAs for 48 h and genomic occupancy of Rad21 measured by ChIP-qPCR. The genomic sites (x-axis) are all co-occupied by both Wapal and Rad21. All sites demonstrated statistically significant enrichment in the empty vector sample compared with input (p value <0.05). Plus symbol indicates a statistically significant reduction from empty vector (p value <0.05)