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Table 2 MS-MLPA analysis of the imprinted locus Beckwith–Wiedemann/Silver–Russell (BWS/SRS) on chromosome 11 for WT1, WT2, FXS1 and FXS2 before and after treatment with 5-azadC [1 ÂµM] at three different time points (T1, T3 and T8)

From: Genome-wide methylation analysis demonstrates that 5-aza-2-deoxycytidine treatment does not cause random DNA demethylation in fragile X syndrome cells

Probes

WT1 UT ratio

WT1 T1 ratio

WT1 T3 ratio

WT1 T8 ratio

11-002.0 H19

0

0

0

0

11-002.0 H19

0.49

0.24≪

0.26≪

0.51

11-002.0 H19

0.54

0.37≪

0.41≪

0.57

11-002.0 H19

0.49

0.28≪

0.32≪

0.55

11-002.1 IGF2

0

0

0

0

11-002.7 KCNQOT1

0.53

0.38

0.39

0.57

11-002.7 KCNQOT1

0.46

0.28≪

0.33≪

0.51

11-002.7 KCNQOT1

0.45

0.33

0.37

0.54

11-002.7 KCNQOT1

0.41

0.3

0.37

0.58

11-002.9 CDKN1c

0.17

0.18

0.2

0.15

Probes

WT2 UT ratio

WT2 T1 ratio

WT2 T3 ratio

WT2 T8 ratio

11-002.0 H19

0.23

0

0

0

11-002.0 H19

0.55

0.26≪

0.26≪

0.47

11-002.0 H19

0.54

0.37≪

0.35≪

0.5

11-002.0 H19

0.52

0.35

0.36

0.51

11-002.1 IGF2

0

0

0

0

11-002.7 KCNQOT1

0.48

0.41

0.29≪

0.59

11-002.7 KCNQOT1

0.44

0.33≪

0.22≪

0.52

11-002.7 KCNQOT1

0.42

0.34

0.26≪

0.5

11-002.7 KCNQOT1

0.42

0.35

0.18≪

0.56

11-002.9 CDKN1c

0.13

0.15

0

0.15

Probes

FXS1 UT ratio

FXS1 T1 ratio

FXS1 T3 ratio

FXS1 T8 ratio

11-002.0 H19

0.23

0.05

0.07

0.07

11-002.0 H19

0.54

0.1≪

0.09≪

0.1

11-002.0 H19

0.62

0.42≪

0.47<

0.59

11-002.0 H19

0.59

0.32≪

0.45

0.49

11-002.1 IGF2

0.02

0.03

0.02

0.02

11-002.7 KCNQOT1

0.59

0.42

0.54

0.6

11-002.7 KCNQOT1

0.59

0.33≪

0.44

0.54

11-002.7 KCNQOT1

0.51

0.42

0.53

0.5

11-002.7 KCNQOT1

0.54

0.36

0.49

0.58

11-002.9 CDKN1c

0.1

0.13

0.16

0.1

Probes

FXS2 UT ratio

FXS2 T1 ratio

FXS2 T3 ratio

FXS2 T8 ratio

11-002.0 H19

0

0

0.19

0

11-002.0 H19

0.26

0.22

0.23

0.29

11-002.0 H19

0.67

0.37≪

0.42≪

0.47

11-002.0 H19

0.71

0.47≪

0.34≪

0.77

11-002.1 IGF2

0.19

0.14

0.11

0.18

11-002.7 KCNQOT1

0.5

0.34

0.68

0.6

11-002.7 KCNQOT1

0.4

0.42

0.44

0.42

11-002.7 KCNQOT1

0.55

0.4

0.74

0.58

11-002.7 KCNQOT1

0.5

0.47

0.44

0.92

11-002.9 CDKN1c

0.25

0.28

0.3

0.35

  1. Only methylation-sensitive probes are listed
  2. The italic values represent levels of methylation lower than 30 %, bold italic values represent those between 30 and 70 %, while underlined values represent those higher than 70 %