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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: Genome-wide methylation analysis demonstrates that 5-aza-2-deoxycytidine treatment does not cause random DNA demethylation in fragile X syndrome cells

Fig. 3

Bisulphite analysis of the FMR1 methylation boundary after 5-azadC treatment. A scheme of the methylation boundary in the 5′ UTR of the FMR1 locus is reported in the upper part of the figure. Bisulphite sequencing of the methylation boundary including the CpG island of the FMR1 promoter region before (upper panel) and after treatment (bottom panel) with 5-azadC for 7 days of WT1 revealed no substantial modification of the methylation profile (a), while an almost complete demethylation of the promoter region that does not affect the methylation boundary was observed in FXS1 after treatment (b). The methylation boundary is indicated by the arrow

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Epigenetics & Chromatin

ISSN: 1756-8935