Fig. 1
From: Tissue-independent and tissue-specific patterns of DNA methylation alteration in cancer
Tissue-independent cancer DNA methylation patterns. a Top heatmap depicts the DNA methylation values of 1500 top-ranked cu-GPs, ranked by level of hypermethylation in colon cancer (COAD), across all fetal tissue types, adult normal tissue and age-matched cancer types from the TCGA. Lower heatmap is the analog for top 1500 cu-GPs, ranked according to hypermethylation in breast cancer (BRCA). In every case, we show the average DNAm values in each phenotype. b Upper diagonal Scatterplots of average DNAm levels of the 8360 cu-GPs between each cancer type. Lower diagonal corresponding R 2 (Pearson) correlation values. c Heatmap of correlation R 2 values of the average DNAm levels of the 8360 cu-GPs in a given cancer type against the corresponding DNAm levels in normal tissue