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Fig. 7 | Epigenetics & Chromatin

Fig. 7

From: Oestrogen receptor β regulates epigenetic patterns at specific genomic loci through interaction with thymine DNA glycosylase

Fig. 7

TDG regulates genes associated with DMPs in ESCs. a Venn diagram showing the overlap of hypo- and hypermethylated DMPs in βerko MEFs identified by RRBS with datasets for 5fC enrichment in deficient (Tdg −/−) or proficient (Tdg fl/fl) ESCs [16] using GenomeInspector (Genomatix). Hypo and hyper refer to the hypo- and hypermethylated regions identified in this study, respectively. b Enrichment (log2 ratios of observed over random) of 5fC in deficient (Tdg −/−) or proficient (Tdg fl/fl) ESCs at differently methylated positions. c TDG dependency of differentially methylated genes in ESCs. Gene expression in TDG-deficient (Tdg −/− pvector) and TDG-complemented (Tdg −/− pTDG) cells was assessed by qRT-PCR (means + SD; n = 3). Asterisk indicates significant (p < 0.05) increase in TDG-proficient vs. TDG-deficient cells

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Epigenetics & Chromatin

ISSN: 1756-8935