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Fig. 5 | Epigenetics & Chromatin

Fig. 5

From: Profiling placental and fetal DNA methylation in human neural tube defects

Fig. 5

Identification and investigation of persistent hits in spina bifida kidneys. a By comparing our spina bifida (SB) and control (CON) samples to an independent control group (n = 5, GEO CON), 748 of the differentially methylated kidney spina bifida CpG sites were identified as persistent hits. Persistent hits were enriched for CpG sites located in enhancers and outside of CpG islands. b Hierarchical clustering of our spina bifida and control samples based solely on persistent hits almost completely separated the spina bifida from control cases, and two groups of SB cases emerged

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