Fig. 4

Differentially methylated CpG sites in the chorionic villi comparison of anencephaly cases to controls. Four CpG sites were identified as significantly differentially methylated at an FDR <0.05 and deltaβ ≥0.05. Each plot is labeled with the 450k CpG site identifier, the gene which it is closest to and average difference in DNAm between anencephaly and controls (deltaβ). Box edges are plotted at the 25th and 75th percentiles (the inter-quartile range (IQR)) and whiskers are plotted to the last sample within ± 1.5*IQR