Epigenetics & Chromatin

Table 2 Overexpression of dKDM5/LID rescues the Sin3A knockdown curved wing phenotype in female flies

From: The histone demethylase dKDM5/LID interacts with the SIN3 histone deacetylase complex and shares functional similarities with SIN3

Genotype	♂		♀
Genotype	% Curly	Flies scored	% Curly	Flies scored
SIN3 KD I	100		100
SIN3 KD II	100		100
SIN3 KD I/EGFP ⁽²⁾	100	50	100	92
SIN3 KD I/LID ⁽³⁾	100	134	4.5 ± 7.7	303
SIN3 KD II/LID ⁽²⁾	100	122	3.8 ± 5.4	132
SIN3 KD I/LID-JmjC* ⁽²⁾	100	100	97.5 ± 2.2	175

Flies constitutively knocked down for Sin3A (SIN3 KD) in wing imaginal discs were crossed to UAS overexpression fly lines for EGFP (control), lid or mutant lid and the progeny counted and analyzed for curved wings
⁽ⁿ⁾ Number of trials
KD knockdown

Back to article page

ISSN: 1756-8935

Contact us

Submission enquiries: journalsubmissions@springernature.com