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Table 1 High-stringent nuclear RNAi-repressed heat-inducible genes (NHGs)

From: A transgenerational role of the germline nuclear RNAi pathway in repressing heat stress-induced transcriptional activation in C. elegans

Gene name Chr Transposon Note
AC8.10 X MuDR transposable element AC8.10/11 and AC8.3/4 are two duplicated neighboring sequences
AC8.11 X MuDR transposable element  
AC8.3 X MuDR transposable element  
AC8.4 X MuDR transposable element  
B0491.2.1 (sqt-1) II No obvious transposable elements around sqt-1 encodes a cuticle collagen; during larval and adult development, sqt-1 activity is required, likely redundantly, for normal cuticle, and hence organismal, morphology
C13B9.4a.1 (pdfr-1) III A short CER9 LTR in an intron pdfr-1 encodes, by alternative splicing, three isoforms of a G-protein-coupled receptor (GPCR) required for normal locomotion
C13B9.4b.1 III A short CER9 LTR in an intron  
C13B9.4c.1 III A short CER9 LTR in an intron  
C18D4.6a V Several repeats, a short Tc1A at 3’ of the gene  
C40A11.10 II Several repeats around the gene  
C44B12.6 IV Several repeats around the gene C44B12.6 is an ortholog of human IL25 (interleukin 25), IL17C (interleukin 17C), IL17B (interleukin 17B), IL17D (interleukin 17D), and IL17A (interleukin 17A); C44B12.6 is predicted to have cytokine activity, based on protein domain information
C49C3.12 (clec-197) IV No obvious transposable elements around C-type LECtin
C50F4.3 (tag-329) V No obvious transposable elements around tag-329 is an ortholog of human CTSL (cathepsin L), CTSV (cathepsin V) and CTSO (cathepsin O); tag-329 is predicted to have cysteine-type peptidase activity, based on protein domain information
C52E2.6 (fbxb-97) II No obvious transposable elements around F-box B protein
F40D4.13 V CER15  
F41G4.5 X CER12  
F41G4.7 X CER12  
F55D10. 3 (glit-1) X No obvious transposable elements in the gene except some repeats around the gene glit-1 is an ortholog of human TG (thyroglobulin)
F57G4.9 V Repeat Turmoil2, Haringer Family This gene was determined to be of Transposon in origin so has been supressed from the C. elegans protein set
F58H7.5 IV CER3 (gypsy)  
F58H7.7 IV CER3 (gypsy)  
F59B2.12 III No obvious transposable elements around  
M7.9 IV No obvious transposable elements around  
R09H3.3 X CER12-I ~ 4 kb downstream  
T10D4.4 (ins-31) II Several repeats around the gene ins-31 encodes an insulin-like peptide of the insulin superfamily of proteins (OMIM: 176730, 147440); INS-31 is one of 38 insulin-like peptides in C. elegans, but is unique in that it contains three insulin repeats; although overexpression with INS-19 can result in low levels of larval lethality, the precise role of INS-31 in C. elegans development is not yet clear as INS-31/19 overexpression does not enhance dauer arrest in either a wild-type or daf-2 mutant background, and loss of INS-31 function does not result in a mutant phenotype
T11F9.10 V CER15 Paralog of F40D.13, both overlaps with CER15
T11F9.18 (srh-1) V upstream to CER15  
W08F4.9 (fbxb-14) II No obvious transposable elements in the gene except some repeats around the gene fbxb-14 (F-box B protein)
Y37H2A.4 (fbxa-107) V CER3 ~ 500 bp upstream F-box A protein. This gene encodes a protein containing an F-box, a motif predicted to mediate protein–protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene’s encoded protein also contains an FTH/DUF38 motif, which may also mediate protein–protein interaction
Y38H6 C .5 (dct-10) V CER3-I in gene body, Tc4 right downstream dct-10 (DAF-16/FOXO Controlled, germline Tumor affecting), dct-10 is predicted to have nucleic acid binding activity and zinc ion binding activity, based on protein domain information
Y43F4A.3 III CER9  
Y53F4B.10 II Several repeats around the gene Y53F4B.10 is orthologous to the human gene INSULIN (IRF4; OMIM: 176730), which when mutated leads to disease
Y56A3A.5 III Several repeats in and around the gene faah-5 is an ortholog of human FAAH (fatty acid amide hydrolase) and FAAH2 (fatty acid amide hydrolase 2); faah-5 is predicted to have carbon–nitrogen ligase activity, with glutamine as amido-N-donor, based on protein domain information
Y68A4A.13 V Several repeats in and around the gene  
Y77E11A.3 IV Several repeats around the gene  
Y79H2A.4 III Several Repeat around the gene Y79H2A.4 is an ortholog of human NDUFAB1 (NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1); Y79H2A.4 is predicted to have nucleotide binding activity, based on protein domain information
ZC15.1 V CER12-I downstream  
ZC15.10 V CER12-I upstream  
ZC15.3 V CER12  
ZK262.8 V CER8  
ZK262.9 V CER8