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Fig. 2 | Epigenetics & Chromatin

Fig. 2

From: Making sense of GWAS: using epigenomics and genome engineering to understand the functional relevance of SNPs in non-coding regions of the human genome

Fig. 2

Prioritizing SNPs using functional annotation. Shown is a figure produced using the Enlight program. a Shown is an index SNP (rs2071278, indicated by the purple diamond) for Rheumatoid Arthritis and correlated SNPs within ±20 Kb; the high LD SNPs (r 2 > 0.8) are indicated in orange. b Shown is the chromHMM segmentation for the region, with the colors (defined in the inset box) indicating the different chromatin states for that region in the blood cell lines, GM12878 and K562; note that the High LD SNPs fall into enhancer categories (yellow bars). c Shown are the genes within the region. d Shown is an eQTL plot with scores based on −log10 P values, taken from the UChicago eQTL browser. e Shown is H3K27Ac and DNase-seq data for GM12878 and K562 and the TFs ChIP-seq track from the ENCODE browser

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