Fig. 6

Expression of loci adjacent to ERV iiDMRs. The average expression from four technical replicates is shown for two genes, Slc15a2 (a) and 2610035D17Rik (b), in which ERV iiDMR 7 and ERV iiDMR 24, respectively, are located. The location of each IAP is indicated relative to the exonic and intronic sequences of genes, indicated by bars connected by lines. Also shown embedded in each expression bar is the liver methylation level of the iiDMR taken from Figs. 4 and 5. The average expression from two technical replicates is shown for two genes, Ccdc21 (c) and Pik3c3 (d), associated with ERV iiDMR 11 and ERV iiDMR 27, respectively. The ERV iiDMR 11 RLTR4 is located in intron 3 of Ccdc21 while the ERV iiDMR 27 RLTR4 is located approximately 5 kb upstream of the Pik3c3 transcription start site. Error bars indicate the SEM for each technical replicate