Fig. 6

Macro-scale genomic associations of RNA:DNA hybrids. We used a least absolute shrinkage and selection operator (LASSO) adaptive regression approach to explore the association of genomic sequence features with RNA:DNA hybrid density in 500 kb windows. The figure shows the order in which covariates enter the model as the constraint on the sum of the regression coefficients (x axis) is progressively relaxed from 0 to its maximum value (corresponding to the ordinary least squares regression vector)