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Fig. 2 | Epigenetics & Chromatin

Fig. 2

From: Tip60 complex binds to active Pol II promoters and a subset of enhancers and co-regulates the c-Myc network in mouse embryonic stem cells

Fig. 2

Tip60 locates to Pol II positive genes. a The heatmaps represents k-means clustering of Tip60, Pol II (GSM307623) and H3K4me3 (GSM307618) binding at all ENSEMBL TSSs. The Input (GSM798320) serves as control. Three main clusters are observed, as indicated. Tip60 is enriched at all Pol II and H3K4me3 positive promoters. b Average binding profiles of Tip60, H3K4me3 and Pol II in a region of 1 kb around active TSSs are depicted. Reads were normalized to Input. The input serves as control. c After extracting all Pol II positive ENSEMBL TSSs, k-means clustering was performed using Tip60 (GSE69671), Pol II (GSM307623), Nsl1 (GSM1300940) and Msl1 (GSM1300939) data sets. d Average binding profiles of Tip60, Nsl1 and Msl1 in a region of 1 kb around active TSSs are depicted. Reads were normalized to input. The input (GSM798320) serves as control. The colour scale bars under each data set in a and c reflect the read densities between 1 and 25 of the given dataset. The number of reads of each dataset is indicted in the colour scale bars in millions (mio) of reads. e Average binding profiles of Tip60, H4K16ac (GSM1056596), H3K9ac (GSM775313) and H3K27ac (GSM594578) in a region of 1 kb around active TSSs was calculated. Reads were normalized to input. To be able to better compare the datasets, the H3K27ac tag densities were divided by five. The Input (GSM798320) serves as control

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