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Table 2 Biological process and cellular component gene ontologies represented in hypomethylated CpG sites in naïve CD4+ T cells from healthy African-Americans

From: Ethnicity-specific epigenetic variation in naïve CD4+ T cells and the susceptibility to autoimmunity

GO term GO term ID Fold enrichment False discovery rate (%) Gene count Genes
Positive regulation of apoptosis GO:0043065 3.0 8.4 10 TNFRSF10A, COL18A1, CDKN1A, AHRR, UNC13D, RIPK1, GRIN1, AKAP13, VAV2, PRODH
Positive regulation of programmed cell death GO:0043068 3.0 8.7 10 TNFRSF10A, COL18A1, CDKN1A, AHRR, UNC13D, RIPK1, GRIN1, AKAP13, VAV2, PRODH
Regulation of kinase activity GO:0043549 3.3 9.0 9 TNFRSF10A, NCK2, CDKN1A, DAB1, ADCY9, RIPK1, CD81, CERK, VAV2
Positive regulation of cell death GO:0010942 3.0 9.0 10 TNFRSF10A, COL18A1, CDKN1A, AHRR, UNC13D, RIPK1, GRIN1, AKAP13, VAV2, PRODH
Regulation of transferase activity GO:0051338 3.2 11.3 9 TNFRSF10A, NCK2, CDKN1A, DAB1, ADCY9, RIPK1, CD81, CERK, VAV2
Positive regulation of kinase activity GO:0033674 4.0 12.6 7 TNFRSF10A, DAB1, ADCY9, RIPK1, CD81, CERK, VAV2
Regulation of leukocyte activation GO:0002694 4.7 13.1 6 NCK2, CDKN1A, UNC13D, AP3D1, CD226, RC3H1
Positive regulation of transferase activity GO:0051347 3.8 14.9 7 TNFRSF10A, DAB1, ADCY9, RIPK1, CD81, CERK, VAV2
Regulation of cell activation GO:0050865 4.5 16.0 6 NCK2, CDKN1A, UNC13D, AP3D1, CD226, RC3H1
Induction of apoptosis GO:0006917 3.3 16.4 8 TNFRSF10A, CDKN1A, AHRR, UNC13D, RIPK1, AKAP13, VAV2, PRODH
Induction of programmed cell death GO:0012502 3.3 16.6 8 TNFRSF10A, CDKN1A, AHRR, UNC13D, RIPK1, AKAP13, VAV2, PRODH
Regulation of cell communication GO:0010646 2.0 17.2 16 PLAT, GNAI3, KLK5, GRIN1, AKAP13, RGNEF, VAV2, ARHGEF10, TNFRSF10A, NCK2, ADAP2, RIPK1, ZDHHC13, CD81, CD226, KNDC1