Table 2 Biological process and cellular component gene ontologies represented in hypomethylated CpG sites in naïve CD4+ T cells from healthy African-Americans
From: Ethnicity-specific epigenetic variation in naïve CD4+ T cells and the susceptibility to autoimmunity
| GO term | GO term ID | Fold enrichment | False discovery rate (%) | Gene count | Genes |
|---|---|---|---|---|---|
| Positive regulation of apoptosis | GO:0043065 | 3.0 | 8.4 | 10 | TNFRSF10A, COL18A1, CDKN1A, AHRR, UNC13D, RIPK1, GRIN1, AKAP13, VAV2, PRODH |
| Positive regulation of programmed cell death | GO:0043068 | 3.0 | 8.7 | 10 | TNFRSF10A, COL18A1, CDKN1A, AHRR, UNC13D, RIPK1, GRIN1, AKAP13, VAV2, PRODH |
| Regulation of kinase activity | GO:0043549 | 3.3 | 9.0 | 9 | TNFRSF10A, NCK2, CDKN1A, DAB1, ADCY9, RIPK1, CD81, CERK, VAV2 |
| Positive regulation of cell death | GO:0010942 | 3.0 | 9.0 | 10 | TNFRSF10A, COL18A1, CDKN1A, AHRR, UNC13D, RIPK1, GRIN1, AKAP13, VAV2, PRODH |
| Regulation of transferase activity | GO:0051338 | 3.2 | 11.3 | 9 | TNFRSF10A, NCK2, CDKN1A, DAB1, ADCY9, RIPK1, CD81, CERK, VAV2 |
| Positive regulation of kinase activity | GO:0033674 | 4.0 | 12.6 | 7 | TNFRSF10A, DAB1, ADCY9, RIPK1, CD81, CERK, VAV2 |
| Regulation of leukocyte activation | GO:0002694 | 4.7 | 13.1 | 6 | NCK2, CDKN1A, UNC13D, AP3D1, CD226, RC3H1 |
| Positive regulation of transferase activity | GO:0051347 | 3.8 | 14.9 | 7 | TNFRSF10A, DAB1, ADCY9, RIPK1, CD81, CERK, VAV2 |
| Regulation of cell activation | GO:0050865 | 4.5 | 16.0 | 6 | NCK2, CDKN1A, UNC13D, AP3D1, CD226, RC3H1 |
| Induction of apoptosis | GO:0006917 | 3.3 | 16.4 | 8 | TNFRSF10A, CDKN1A, AHRR, UNC13D, RIPK1, AKAP13, VAV2, PRODH |
| Induction of programmed cell death | GO:0012502 | 3.3 | 16.6 | 8 | TNFRSF10A, CDKN1A, AHRR, UNC13D, RIPK1, AKAP13, VAV2, PRODH |
| Regulation of cell communication | GO:0010646 | 2.0 | 17.2 | 16 | PLAT, GNAI3, KLK5, GRIN1, AKAP13, RGNEF, VAV2, ARHGEF10, TNFRSF10A, NCK2, ADAP2, RIPK1, ZDHHC13, CD81, CD226, KNDC1 |