Fig. 4
From: Ethnicity-specific epigenetic variation in naïve CD4+ T cells and the susceptibility to autoimmunity
The CpG-SNP rs55661361 (A > G) in NRGN has an allele frequency that differs between CEU and YRI populations (a). Bisulfite sequencing of the CpG-SNP region in healthy individuals (b) revealed three distinct methylation categories based on being heterozygous or homozygous for the disruptive A allele [high methylation (G/G); intermediate methylation (G/A); low methylation (A/A)]. A cartoon (c) demonstrating the effect of the A allele on cytosine methylation by DNMT1. Average DNA methylation levels in NRGN stratified by genotype in 31 healthy individuals included in the study (d). Genotype, average methylation ± SD, N: G/G, 0.82 ± 0.07, N = 15; G/A, 0.56 ± 0.07, N = 13; A/A, 0 ± 0, N = 3