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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: Ethnicity-specific epigenetic variation in naïve CD4+ T cells and the susceptibility to autoimmunity

Fig. 3

Analysis of the transcriptional correlation of 144 genes hypomethylated in African-American naïve CD4+ T cells was conducted by calculating Pearson’s correlation coefficients of the reported transcriptional fold changes across 3900 human 2-color microarray data sets. Correlation values range from 1.0 (perfect positive correlation represented in red) to −1.0 (perfect negative correlation represented in green). Three blocks of transcriptionally co-regulated genes can be seen in the colored squares. Using literature mining, the highest scoring themes among the genes in the yellow, blue and purple blocks are the cytokine IL-2, cell migration, and the glutathione S-transferase gene GSTO1, respectively

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