Table 1 Population characteristics of discovery sample KORA F4, replication sample KORA F3, and replication studies ALSPAC and EPICOR
From: Characterization of whole-genome autosomal differences of DNA methylation between men and women
Discovery | Replication | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
KORA F4 | KORA F3 | ALSPAC | EPICOR | |||||||||
All | Males | Females | All | Males | Females | All | Males | Females | All | Males | Females | |
N | 1799 | 877 | 922 | 500 | 260 | 240 | 963 | 499 | 464 | 536 | 340 | 196 |
Age range (years) | 32–81 | 35–79 | 32–81 | 34–83 | 34–77 | 35–83 | 14–19 | 14–19 | 15–19 | 35–71 | 35–64 | 35–71 |
Mean age | 60 (8.89) | 61 (8.92) | 60 (8.85) | 53 (9.64) | 53 (9.80) | 52 (9.48) | 17.10 (1.00) | 17.10 (1.10) | 17.10 (1.00) | 52.90 (7.38) | 51.45 (6.95) | 55.40 (7.45) |
BMI (kg/m2) | 28.15 (4.80) | 28.39 (4.27) | 27.93 (5.24) | 27.16 (4.54) | 27.22 (3.97) | 26.55 (5.07) | 22.32 (3.84) | 22.48 (4.08) | 22.15 (3.55) | 26.65 (3.87) | 26.66 (3.07) | 26.63 (4.96) |
% Smokers | 14.58 | 16.23 | 13.02 | 50.00 | 50.00 | 50.00 | NA | NA | NA | 32.83 | 35.29 | 28.57 |
Alcohol intake (g/days) | 15.49 (20.43) | 22.93 (24.17) | 8.44 (12.53) | 16.11 (19.59) | 21.86 (21.79) | 9.17 (14.10) | NA | NA | NA | 17.99 (20.13) | 24.08 (20.79) | 7.43 (13.54) |
Triglycerides (mmol/L) | 1.52 (1.08) | 1.72 (1.28) | 1.34 (0.81) | 1.88 (1.39) | 2.18 (1.67) | 1.56 (0.92) | 0.84 (0.37) | 0.83 (0.32) | 0.84 (0.41) | 1.72 (1.06) | 1.81 (1.02) | 1.57 (1.12) |
Total cholesterol (mmol/L) | 5.73 (1.02) | 5.58 (1.00) | 5.87 (1.01) | 5.70 (0.99) | 5.61 (1.03) | 5.80 (0.93) | 3.74 (0.68) | 3.91 (0.69) | 3.56 (0.63) | 6.13 (1.19) | 5.99 (1.17) | 6.39 (1.19) |
HDL (mmol/L) | 1.46 (0.38) | 1.32 (0.33) | 1.59 (0.37) | 1.51 (0.46) | 1.33 (0.40) | 1.69 (0.45) | 1.25 (0.30) | 1.32 (0.32) | 1.18 (0.26) | 1.48 (0.39) | 1.38 (0.34) | 1.65 (0.41) |
LDL (mmol/L) | 3.62 (0.91) | 3.57 (0.88) | 3.66 (0.93) | 3.39 (0.86) | 3.39 (0.84) | 3.38 (0.87) | 2.10 (0.60) | 2.21 (0.63) | 1.99 (0.55) | 3.87 (1.05) | 3.78 (1.02) | 4.02 (1.09) |
% Physical activity | ||||||||||||
No | 31.27 | 26.97 | 23.97 | 32.20 | 25.38 | 16.25 | NA | NA | NA | 21.27 | 15.88 | 30.61 |
Low | 11.52 | 28.23 | 35.14 | 18.00 | 24.62 | 33.33 | NA | NA | NA | 43.84 | 41.18 | 48.47 |
Medium | 31.78 | 12.23 | 10.85 | 28.80 | 18.85 | 17.08 | NA | NA | NA | 17.54 | 21.76 | 10.2 |
High | 25.43 | 32.57 | 30.04 | 21.00 | 31.15 | 33.33 | NA | NA | NA | 17.35 | 21.18 | 10.72 |
% Diabetic | 9.23 | 10.27 | 8.24 | 6.20 | 8.46 | 3.75 | NA | NA | NA | 1.68 | 1.18 | 2.55 |
% MI | 3.562 | 5.59 | 1.63 | 1.60a | 2.31a | 0.83a | NA | NA | NA | 52.98 | 53.23 | 52.55 |