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Table 1 Population characteristics of discovery sample KORA F4, replication sample KORA F3, and replication studies ALSPAC and EPICOR

From: Characterization of whole-genome autosomal differences of DNA methylation between men and women

  Discovery Replication
KORA F4 KORA F3 ALSPAC EPICOR
All Males Females All Males Females All Males Females All Males Females
N 1799 877 922 500 260 240 963 499 464 536 340 196
Age range (years) 32–81 35–79 32–81 34–83 34–77 35–83 14–19 14–19 15–19 35–71 35–64 35–71
Mean age 60 (8.89) 61 (8.92) 60 (8.85) 53 (9.64) 53 (9.80) 52 (9.48) 17.10 (1.00) 17.10 (1.10) 17.10 (1.00) 52.90 (7.38) 51.45 (6.95) 55.40 (7.45)
BMI (kg/m2) 28.15 (4.80) 28.39 (4.27) 27.93 (5.24) 27.16 (4.54) 27.22 (3.97) 26.55 (5.07) 22.32 (3.84) 22.48 (4.08) 22.15 (3.55) 26.65 (3.87) 26.66 (3.07) 26.63 (4.96)
% Smokers 14.58 16.23 13.02 50.00 50.00 50.00 NA NA NA 32.83 35.29 28.57
Alcohol intake (g/days) 15.49 (20.43) 22.93 (24.17) 8.44 (12.53) 16.11 (19.59) 21.86 (21.79) 9.17 (14.10) NA NA NA 17.99 (20.13) 24.08 (20.79) 7.43 (13.54)
Triglycerides (mmol/L) 1.52 (1.08) 1.72 (1.28) 1.34 (0.81) 1.88 (1.39) 2.18 (1.67) 1.56 (0.92) 0.84 (0.37) 0.83 (0.32) 0.84 (0.41) 1.72 (1.06) 1.81 (1.02) 1.57 (1.12)
Total cholesterol (mmol/L) 5.73 (1.02) 5.58 (1.00) 5.87 (1.01) 5.70 (0.99) 5.61 (1.03) 5.80 (0.93) 3.74 (0.68) 3.91 (0.69) 3.56 (0.63) 6.13 (1.19) 5.99 (1.17) 6.39 (1.19)
HDL (mmol/L) 1.46 (0.38) 1.32 (0.33) 1.59 (0.37) 1.51 (0.46) 1.33 (0.40) 1.69 (0.45) 1.25 (0.30) 1.32 (0.32) 1.18 (0.26) 1.48 (0.39) 1.38 (0.34) 1.65 (0.41)
LDL (mmol/L) 3.62 (0.91) 3.57 (0.88) 3.66 (0.93) 3.39 (0.86) 3.39 (0.84) 3.38 (0.87) 2.10 (0.60) 2.21 (0.63) 1.99 (0.55) 3.87 (1.05) 3.78 (1.02) 4.02 (1.09)
% Physical activity
 No 31.27 26.97 23.97 32.20 25.38 16.25 NA NA NA 21.27 15.88 30.61
 Low 11.52 28.23 35.14 18.00 24.62 33.33 NA NA NA 43.84 41.18 48.47
 Medium 31.78 12.23 10.85 28.80 18.85 17.08 NA NA NA 17.54 21.76 10.2
 High 25.43 32.57 30.04 21.00 31.15 33.33 NA NA NA 17.35 21.18 10.72
 % Diabetic 9.23 10.27 8.24 6.20 8.46 3.75  NA NA NA 1.68 1.18 2.55
 % MI 3.562 5.59 1.63 1.60a 2.31a 0.83a NA NA NA 52.98 53.23 52.55
  1. Values given as mean (SD), otherwise indicated
  2. aMyocardial infarction with hospital treatment (self-reported)