Fig. 4

Genome-wide distributions of novel H3 variants are classified into H3.1-like or H3.3-like patterns. a Proportion of each incorporated H3 variant localized in three gene regions (promoter, gene body or inter-gene). The proportions were calculated from the ratio of ChIP-Seq peaks detected in the categories. The top lane (Genome) indicates the proportion (%) of each category with random (uniform) distribution on the genome to enable comparison. The other lanes are proportions of detected peaks for the H3.1 and H3.3 groups. b The distribution of H3 variants focused on gene loci. Data for the H3.1-type variant is shown as a control. The x-axis shows the relative coordinate of the gene from the TSS to the TES (transcription end site). The y-axis shows the average ChIP-Seq and the input signal intensity over all mouse genes. c Distribution of H3.3-type variants around the TSSs of all genes. The order of genes (rows) was determined by hierarchical clustering using total log₂FCs within 5 kb from the TSSs. Higher fold-change (FC) is indicated by thicker black shading